Syntheses and evaluation as antifolates of MTX analogues derived from 2,w-diaminoalkanoic acids

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Bibliographic Details
Published inJournal of medicinal chemistry Vol. 28; no. 8; pp. 1016 - 1025
Main Authors PIPER, J. R, MCCALEB, G. S, MONTGOMERY, J. A, SCHMID, F. A, SIROTNAK, F. M
Format Journal Article
LanguageEnglish
Published Washington, DC American Chemical Society 1985
Subjects
Chemistry
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings
Organic chemistry
Preparations and properties
Antineoplastic agent
Antifolate
Diamine
Nitrogen heterocycle
Nitrosoureas
Aminoacid
Bicyclic compound
Ureas
Guanidines
L1210-Leukemia
In vitro
Biological activity
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ISSN:0022-2623
1520-4804