6-Azasteroids : structure-activity relationships for inhibition of type 1 and 2 human 5α-reductase and human adrenal 3β-hydroxy-Δ5-steroid dehydrogenase/3-keto-Δ5-steroid isomerase

• Published in: Journal of medicinal chemistry Vol. 37; no. 15; pp. 2352 - 2360
• Main Authors: FRYE, S. V, HAFFNER, C. D, BATCHELOR, K. W, BRAMSON, H. N, STUART, J. D, SCHWEIKER, S. L, VAN ARNOLD, J, CROOM, S, BICKETT, D. M, MOSS, M. L, TIAN, G, UNWALLA, R. J, MALONEY, P. R, LEE, F. W, TIPPIN, T. K, JAMES, M. K, GRIZZLE, M. K, LONG, J. E, SCHUSTER, S. V, MOOK, R. A, DORSEY, G. F, HINER, R. N, CRIBBS, C. M, WHEELER, T. N, RAY, J. A, ANDREWS, R. C
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 1994
• Subjects: Alicyclic compounds, terpenoids, prostaglandins, steroids; Chemistry; Exact sciences and technology; Organic chemistry; Preparations and properties; Steroids; Antineoplastic agent; Steroid; Intravenous administration; Intramolecular oxidoreductases; Rat; Nitrogen heterocycle; Hyperplasia; Isomerases; Structure activity relation; Benign neoplasm; Dog; Fissipedia; Carnivora; Enzyme; Rodentia; Oral administration; Cholestenone 5α-reductase; Tetracyclic compound; Azasteroid; Prostatic disease; In vivo; Vertebrata; Mammalia; Animal; Steroid Δ-isomerase; Carboxamide; Oxidoreductases; Pharmacokinetics
• ISSN: 0022-2623; 1520-4804