Monocyclic β-lactam inhibitors of human leukocyte elastase. Stereospecific synthesis and activity of 3,4-disubstituted-2-azetidinones Recent advances in the chemistry and biology of β-lactams and β-lactam antibiotics

• Published in: Bioorganic & medicinal chemistry letters Vol. 3; no. 11; pp. 2295 - 2298
• Main Authors: SHAH, S. K, FINKE, P. E, BRAUSE, K. A, CHANDLER, G. O, ASHE, B. M, WESTON, H, MAYCOCK, A. L, MUMFORD, R. A, DOHERTY, J. B
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier 1993
• Subjects: Biological and medical sciences; Bones, joints and connective tissue. Antiinflammatory agents; Medical sciences; Pharmacology. Drug treatments; Human; Leukocyte elastase; Serine endopeptidases; Molecular structure; Enzyme; Lactam; Monkey; Oral administration; Enzyme inhibitor; Bioavailability; Chemical substitution; Hydrolysis; Vertebrata; Mammalia; Enzymatic activity; Animal; Azetidine derivatives; Primates; Hydrolases; Stereospecificity; Pharmacokinetics; Chemical synthesis; Proteinases; Monocyclic compound
• ISSN: 0960-894X; 1464-3405