Acyl-CoA : Cholesterol O-acyltransferase (ACAT) inhibitors. II. 2-(1,3-dioxan-2-yl)-4,5-diphenyl-1H-imidazoles as potent inhibitors of ACAT

• Published in: Journal of medicinal chemistry Vol. 39; no. 7; pp. 1423 - 1432
• Main Authors: ASTLES, P. C, ASHTON, M. J, BRIDGE, A. W, HARRIS, N. V, HART, T. W, PARROTT, D. P, PORTER, B, RIDDELL, D, SMITH, C, WILLIAMS, R. J
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 1996
• Subjects: Biological and medical sciences; General and cellular metabolism. Vitamins; Medical sciences; Pharmacology. Drug treatments; Imidazole derivatives; Rat; Liver; Rabbit; Prevention; Structure activity relation; Atherosclerosis; Chemical synthesis; Human; Acyltransferases; Dioxane derivatives; Enzyme; Transferases; Rodentia; Oral administration; Enzyme inhibitor; Bioavailability; Lagomorpha; In vitro; Cholesterol; In vivo; Vertebrata; Mammalia; Animal; Piperazine derivatives; Pharmacokinetics; Antilipemic agent; Sterol O-acyltransferase