Acyl-CoA : Cholesterol O-acyltransferase (ACAT) inhibitors. II. 2-(1,3-dioxan-2-yl)-4,5-diphenyl-1H-imidazoles as potent inhibitors of ACAT

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Bibliographic Details
Published inJournal of medicinal chemistry Vol. 39; no. 7; pp. 1423 - 1432
Main Authors ASTLES, P. C, ASHTON, M. J, BRIDGE, A. W, HARRIS, N. V, HART, T. W, PARROTT, D. P, PORTER, B, RIDDELL, D, SMITH, C, WILLIAMS, R. J
Format Journal Article
LanguageEnglish
Published Washington, DC American Chemical Society 1996
Subjects
Biological and medical sciences
General and cellular metabolism. Vitamins
Medical sciences
Pharmacology. Drug treatments
Imidazole derivatives
Rat
Liver
Rabbit
Prevention
Structure activity relation
Atherosclerosis
Chemical synthesis
Human
Acyltransferases
Dioxane derivatives
Enzyme
Transferases
Rodentia
Oral administration
Enzyme inhibitor
Bioavailability
Lagomorpha
In vitro
Cholesterol
In vivo
Vertebrata
Mammalia
Animal
Piperazine derivatives
Pharmacokinetics
Antilipemic agent
Sterol O-acyltransferase
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ISSN:0022-2623
1520-4804