Rational design and synthesis of a novel, selective class of thrombin inhibitors : Pl-ARGININAL derivatives incorporating P3-P4 quaternary lactam dipeptide surrogates

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 7; no. 18; pp. 2421 - 2426
Main Authors SEMPLE, J. E, MINAMI, N. K, TAMURA, S. Y, BRUNCK, T. K, NUTT, R. F, RIPKA, W. C
Format Journal Article
LanguageEnglish
Published Oxford Elsevier 1997
Subjects
Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
Medical sciences
Pharmacology. Drug treatments
Human
Serine endopeptidases
Enzyme
Nitrogen heterocycle
Peptidomimetic compound
Lactam
Enzyme inhibitor
Thrombin
Guanidines
In vitro
Peptidases
Structure activity relation
Dipeptides
Hydrolases
Carboxamide
Chemical synthesis
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ISSN:0960-894X
1464-3405