Evaluation of Cynomolgus Monkey Pregnane X Receptor, Primary Hepatocyte, and in Vivo Pharmacokinetic Changes in Predicting Human CYP3A4 Inductions

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Bibliographic Details
Published inDrug metabolism and disposition Vol. 38; no. 1; pp. 16 - 24
Main Authors KIM, Sean, DINCHUK, Joseph E, DULAC, Heidi A, PIZZANO, Jennifer, SINZ, Michael, ANTHONY, Monique N, ORCUTT, Tami, ZOECKLER, Mary E, SAUER, Mary B, MOSURE, Kathleen W, VUPPUGALLA, Ragini, GRACE, James E, SIMMERMACHER, Jean
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Society for Pharmacology and Experimental Therapeutics 2010
Subjects
Biological and medical sciences
Medical sciences
Pharmacology. Drug treatments
Human
Evaluation
Digestive system
Enzyme
Induction
Isozyme
Liver
Cytochrome P450
Pregnane X receptor
Prediction
Monkey
In vitro
In vivo
Vertebrata
Mammalia
Hepatocyte
Animal
Primary
Primates
Pharmacokinetics
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ISSN:0090-9556
1521-009X