Involvement of P13K-Akt-Bad pathway in apoptosis induced by 2,6-di-O-methyl-β-cyclodextrin, not 2,6-di-O-methyl-α-cyclodextrin, through cholesterol depletion from lipid rafts on plasma membranes in cells

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Bibliographic Details
Published inEuropean journal of pharmaceutical sciences Vol. 38; no. 3; pp. 249 - 261
Main Authors MOTOYAMA, Keiichi, KAMEYAMA, Kazuhisa, ONODERA, Risako, ARAKI, Norie, HIRAYAMA, Fumitoshi, UEKAMA, Kaneto, ARIMA, Hidetoshi
Format Journal Article
LanguageEnglish
Published Kindlington Elsevier 2009
Subjects
Biological and medical sciences
General pharmacology
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Pharmaceutical technology
Akt protein kinase
Lipids
Lipid rafts
Cholesterol
Membrane cell
α-Cyclodextrin
2,6-Di-O-methyl-α-cyclodextrin
2,6-Di-O-methyl-β-cyclodextrin
Depletion
Cell death
Plasma membrane
Inclusion compound
P13K-Akt-Bad
Apoptosis
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ISSN:0928-0987
1879-0720