Identification of Human Metabolites of (-)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisopuinoline-2-carbonyl)piperidino]ethyl-4-fluorobenzamide (YM758), a Novel If Channel Inhibitor, and Investigation of the Transporter-Mediated Renal and Hepatic Excretion of These Metabolites

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Bibliographic Details
Published inDrug metabolism and disposition Vol. 37; no. 8; pp. 1646 - 1657
Main Authors UMEHARA, Ken-Ichi, SHIRAI, Nobuaki, LWATSUBO, Takafumi, NOGUCHI, Kiyoshi, USUI, Takashi, KAMIMURA, Hidetaka
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Society for Pharmacology and Experimental Therapeutics 2009
Subjects
Biological and medical sciences
Medical sciences
Pharmacology. Drug treatments
Human
Carbonyl compounds
Excretion
Digestive system
Metabolite
Liver
Ionic channel
Identification
Kidney
Urinary system
Inhibitor
Pharmacokinetics
Carrier protein
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ISSN:0090-9556
1521-009X