Identification of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimi-dinyl] amines and ethers as potent and selective cyclooxygenase-2 inhibitors

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 19; no. 15; pp. 4504 - 4508
Main Authors SWARBRICK, Martin E, BESWICK, Paul J, COLLINS, Sue D, CORFIELD, John A, HARTLEY, C. David, KLEANTHOUS, Sawas, LAMBETH, Paul F, LUCAS, Fiona S, MATHEWS, Neil, NAYLOR, Alan, PAGE, Lee W, PAYNE, Jeremy J, GLEAVE, Robert J, PEGG, Neil A, PRICE, Helen S, SKIDMORE, John, STEVENS, Alexander J, STOCKER, Richard, STRATTON, Sharon C, STUART, Alastair J, WISEMAN, Joanne O, GREEN, Richard H, BINGHAM, Sharon, BOUNTRA, Chas, CARTER, Malcolm C, CHAMBERS, Laura J, CHESSELL, Lain P, CLAYTON, Nick M
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier 2009
Subjects
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Medical sciences
Pharmacology. Drug treatments
CNS penetrant
Prostaglandin-endoperoxide synthase
Intravenous administration
Rat
Sulfone
COX-2
Nitrogen heterocycle
Cyclooxygenase 2
Cyclooxygenase 2 inhibitor
Selectivity
Blood brain barrier
Pyrimidine
Cyclooxygenase
Structure activity relation
Six membered ring
Chemical synthesis
Enzyme
Rodentia
Benzene derivatives
Oral administration
Enzyme inhibitor
Bioavailability
In vitro
Non steroidal antiinflammatory agent
In vivo
Vertebrata
Mammalia
Animal
Fluorine Organic compounds
Oxidoreductases
Pharmacokinetics
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ISSN:0960-894X
1464-3405