Novel recombinant BCG expressing perfringolysin 0 and the over-expression of key immunodominant antigens; pre-clinical characterization, safety and protection against challenge with Mycobacterium tuberculosis

• Published in: Vaccine Vol. 27; no. 33; pp. 4412 - 4423
• Main Authors: SUN, Ronggai, SKEIKY, Yasir A. W, SCANGA, Charles, GROVER, Ajay, DERRICK, Steven C, MORRIS, Sheldon, HONE, David M, HORWITZ, Marcus A, KAUFMANN, Stefan H. E, SADOFF, Jerald C, IZZO, Angelo, DHEENADHAYALAN, Veerabadran, IMAM, Zakaria, PENN, Erica, STAGLIANO, Katherine, HADDOCK, Scott, MUELLER, Stefanie, FULKERSON, John
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier 2009
• Subjects: Applied microbiology; Bacterial diseases; Bacteriology; Biological and medical sciences; Fundamental and applied biological sciences. Psychology; Human bacterial diseases; Infectious diseases; Medical sciences; Microbiology; Miscellaneous; Tuberculosis and atypical mycobacterial infections; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Prime-boost; T-cell; Vaccination; BCG; Mycobacterial infection; Immunodominance; Infection; Antigen; Antigen over-expression; Tuberculosis; Mycobacterium tuberculosis; Mycobacteriales; T-Lymphocyte; Bacteriosis; Mycobacteriaceae; Bacteria; Actinomycetes; Ad35; Recombinant BCG; Endosome; Protection; Endosome lysis