Novel recombinant BCG expressing perfringolysin 0 and the over-expression of key immunodominant antigens; pre-clinical characterization, safety and protection against challenge with Mycobacterium tuberculosis

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Bibliographic Details
Published inVaccine Vol. 27; no. 33; pp. 4412 - 4423
Main Authors SUN, Ronggai, SKEIKY, Yasir A. W, SCANGA, Charles, GROVER, Ajay, DERRICK, Steven C, MORRIS, Sheldon, HONE, David M, HORWITZ, Marcus A, KAUFMANN, Stefan H. E, SADOFF, Jerald C, IZZO, Angelo, DHEENADHAYALAN, Veerabadran, IMAM, Zakaria, PENN, Erica, STAGLIANO, Katherine, HADDOCK, Scott, MUELLER, Stefanie, FULKERSON, John
Format Journal Article
LanguageEnglish
Published Kidlington Elsevier 2009
Subjects
Applied microbiology
Bacterial diseases
Bacteriology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Human bacterial diseases
Infectious diseases
Medical sciences
Microbiology
Miscellaneous
Tuberculosis and atypical mycobacterial infections
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Prime-boost
T-cell
Vaccination
BCG
Mycobacterial infection
Immunodominance
Infection
Antigen
Antigen over-expression
Tuberculosis
Mycobacterium tuberculosis
Mycobacteriales
T-Lymphocyte
Bacteriosis
Mycobacteriaceae
Bacteria
Actinomycetes
Ad35
Recombinant BCG
Endosome
Protection
Endosome lysis
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ISSN:0264-410X
1873-2518