Synthesis and antitumoral evaluation of indole alkaloid analogues containing an hexahydropyrrolo[1,2,3 :1,9a,9]imidazo[1.2-o]iridole skeleton

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Bibliographic Details
Published inBioorganic & medicinal chemistry Vol. 16; no. 20; pp. 9313 - 9322
Main Authors VENTOSA-ANDRES, Pilar, GONZALEZ-VERA, Juan A, VALDIVIELSO, Angel M, GARCIA-LOPEZ, M. Teresa, HERRANZ, Rosario
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier 2008
Subjects
Antineoplastic agents
Biological and medical sciences
General aspects
Medical sciences
Pharmacology. Drug treatments
Antineoplastic agent
Angular nitrogen heterocycle
Lung
Cytotoxicity
Epidermal growth factor receptor
Signal transduction
Alkaloid
Structure activity relation
Bromine Organic compounds
Aromatic compound
Colon
Mammary gland
Inhibition
Chemical synthesis
Indole alkaloids
Tumor cell
Human
Enzyme
Transferases
Enzyme inhibitor
α-Amino nitriles
Tetracyclic compound
Inhibition of EGFR
In vitro
α-Aminoacid
Amidine
Cell line
Inhibition of HIF-1α
Transcription factor HIF1
Indole derivatives
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ISSN:0968-0896
1464-3391