Discovery and SAR of 2-(l-propylpiperidin-4-yl)-lH-benzimidazole-4-carboxamide : A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer

• Published in: Bioorganic & medicinal chemistry Vol. 16; no. 14; pp. 6965 - 6975
• Main Authors: PENNING, Thomas D, ZHU, Gui-Dong, XUESONG LIU, YAN SHI, KLINGHOFER, Vered, JOHNSON, Eric F, DONAWHO, Cherrie K, FROST, David J, BONTCHEVA-DIAZ, Velitchka, BOUSKA, Jennifer J, OLSON, Amanda M, MARSH, Kennan C, GANDHI, Viraj B, YAN LUO, ROSENBERG, Saul H, GIRANDA, Vincent L, JIANCHUN GONG, THOMAS, Sheela, LUBISCH, Wilfried, GRANDEL, Roland, WERNET, Wolfgang, PARK, Chang H, FRY, Elizabeth H
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier 2008
• Subjects: Antineoplastic agents; Biological and medical sciences; General aspects; Medical sciences; Pharmacology. Drug treatments; Antineoplastic agent; Nitrogen heterocycle; Spontaneous; Glycosyltransferases; Benzimidazole carboxamide; Structure activity relation; Poly(ADP-ribose)polymerase; B16-Melanoma; Piperidine derivatives; Bicyclic compound; ADP-ribosyltransferase; Aromatic compound; Mammary gland; Chemical synthesis; Tumor cell; Human; Enzyme; Transferases; Rodentia; Oral administration; PARP inhibitor; Enzyme inhibitor; A-620223; Malignant tumor; Bioavailability; In vitro; NAD; In vivo; Mammary gland diseases; Vertebrata; Chemotherapy; Mammalia; Treatment; Cell line; Mouse; Animal; Pharmacokinetics; Pentosyltransferases; Cancer