Discovery and SAR of 2-(l-propylpiperidin-4-yl)-lH-benzimidazole-4-carboxamide : A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer

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Bibliographic Details
Published inBioorganic & medicinal chemistry Vol. 16; no. 14; pp. 6965 - 6975
Main Authors PENNING, Thomas D, ZHU, Gui-Dong, XUESONG LIU, YAN SHI, KLINGHOFER, Vered, JOHNSON, Eric F, DONAWHO, Cherrie K, FROST, David J, BONTCHEVA-DIAZ, Velitchka, BOUSKA, Jennifer J, OLSON, Amanda M, MARSH, Kennan C, GANDHI, Viraj B, YAN LUO, ROSENBERG, Saul H, GIRANDA, Vincent L, JIANCHUN GONG, THOMAS, Sheela, LUBISCH, Wilfried, GRANDEL, Roland, WERNET, Wolfgang, PARK, Chang H, FRY, Elizabeth H
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier 2008
Subjects
Antineoplastic agents
Biological and medical sciences
General aspects
Medical sciences
Pharmacology. Drug treatments
Antineoplastic agent
Nitrogen heterocycle
Spontaneous
Glycosyltransferases
Benzimidazole carboxamide
Structure activity relation
Poly(ADP-ribose)polymerase
B16-Melanoma
Piperidine derivatives
Bicyclic compound
ADP-ribosyltransferase
Aromatic compound
Mammary gland
Chemical synthesis
Tumor cell
Human
Enzyme
Transferases
Rodentia
Oral administration
PARP inhibitor
Enzyme inhibitor
A-620223
Malignant tumor
Bioavailability
In vitro
NAD
In vivo
Mammary gland diseases
Vertebrata
Chemotherapy
Mammalia
Treatment
Cell line
Mouse
Animal
Pharmacokinetics
Pentosyltransferases
Cancer
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ISSN:0968-0896
1464-3391