Indole Cytosolic Phospholipase A2 α Inhibitors : Discovery and in Vitro and in Vivo Characterization of 4-{3-[5-Chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-l-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic Acid, Efipladib

• Published in: Journal of medicinal chemistry Vol. 51; no. 12; pp. 3388 - 3413
• Main Authors: MCKEW, John C, LEE, Katherine L, CHEN, Lihren, KIRINCICH, Steven J, MICHALAK, Ronald, THOMASON, Jennifer, IPEK, Manus, KUN WU, WOODER, Lane, RAMARAO, Manjunath K, MURPHY, Elizabeth A, GOODWIN, Debra G, SHEN, Marina W. H, ALBERT, Leo, XIN XU, DONAHUE, Frances, SHERRY KU, M, KEITH, James, NICKERSON-NUTTER, Cheryl L, ABRAHAM, William M, WILLIAMS, Cara, HEGEN, Martin, CLARK, James D, THAKKER, Paresh, FOLEY, Megan A, BEHNKE, Mark L, BAIHUA HU, SUM, Fuk-Wah, TAM, Steve, YONGHAN HU
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 2008
• Subjects: Biological and medical sciences; Bones, joints and connective tissue. Antiinflammatory agents; Medical sciences; Pharmacology. Drug treatments; Rat; Diseases of the osteoarticular system; Esterases; Arthritis; Cytosol; Benzoic acid derivatives; Structure activity relation; Chlorine Organic compounds; Efipladib; Chemical synthesis; Sulfonamide; Prostaglandin; Enzyme; Arachidonic acid derivatives; Rodentia; Antiinflammatory agent; Oral administration; Enzyme inhibitor; In vitro; Phospholipase A; Carboxylic ester hydrolases; In vivo; Leukotriene; Vertebrata; Mammalia; Animal; Hydrolases; Indole derivatives; Pharmacokinetics
• ISSN: 0022-2623; 1520-4804