(R)-3,3,3-trifluoro-2-hydroxy-2-methyl-propionamides are orally active inhibitors of pyruvate dehydrogenase kinase

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Bibliographic Details
Published inJournal of medicinal chemistry Vol. 42; no. 15; pp. 2741 - 2746
Main Authors AICHER, T. D, ANDERSON, R. C, JIANPING GAO, VINLUAN, C. C, SHETTY, S. S, DRAGLAND, C, KAPLAN, E. L, DELGRANDE, D, ISLAM, A, XILIN LIU, LOZITO, R. J, MANIARA, W. M, BEBERNITZ, G. R, WALTER, R. E, MANN, W. R, COPPOLA, G. M, JEWELL, C. F, KNORR, D. C, LIU, C, SPERBECK, D. M, BRAND, L. J, STROHSCHEIN, R. J
Format Journal Article
LanguageEnglish
Published Washington, DC American Chemical Society 1999
Subjects
Biological and medical sciences
General and cellular metabolism. Vitamins
Medical sciences
Pharmacology. Drug treatments
Rat
Nitrogen heterocycle
Hydroxyamide
Glucose
Structure activity relation
Oxidation
R configuration
Chemical synthesis
Anilide
Haloalcohol
Enzyme
Transferases
Rodentia
Oral administration
Enzyme inhibitor
Bioavailability
In vitro
[Pyruvate dehydrogenase (lipoamide)] kinase
In vivo
Vertebrata
Mammalia
Animal
Benzenic compound
Fluorine Organic compounds
Piperazine derivatives
Pharmacokinetics
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ISSN:0022-2623
1520-4804