Structural factors contributing to the Al/Lyn dual inhibitory activity of 3-substituted benzamide derivatives

• Published in: Bioorganic & medicinal chemistry letters Vol. 17; no. 10; pp. 2712 - 2717
• Main Authors: HORIO, Tatsuya, HAMASAKI, Tomohiro, INOUE, Toshihiko, WAKAYAMA, Tatsushi, ITOU, Shinsaku, NAITO, Haruna, ASAKI, Tetsuo, HAYASE, Hiroki, NIWA, Tomoko
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier 2007
• Subjects: Antineoplastic agents; Biological and medical sciences; General aspects; Medical sciences; Pharmacology. Drug treatments; Antineoplastic agent; Nitrogen heterocycle; Binding site; Abl; Modeling; Pyrrolidine derivatives; Pyridine derivatives; Signal transduction; Tyrosine kinase; Structure activity relation; Molecular modeling; Molecular model; X-ray; Protein-tyrosine kinase; Halogen Organic compounds; Human; Lyn; Imatinib; Enzyme; Transferases; Benzene derivatives; Prediction; Enzyme inhibitor; Inhibitor enzyme complex; X ray diffraction; Kinase; QSAR; Azetidine derivatives; Tertiary amine; Benzamide derivatives; Carboxamide; Pyrimidine derivatives; Inhibitor; Piperazine derivatives
• ISSN: 0960-894X; 1464-3405