Dose-independent pharmacokinetics of clindamycin after intravenous and oral administration to ats : Contribution of gastric first-pass effect to low bioavailability

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Bibliographic Details
Published inInternational journal of pharmaceutics Vol. 332; no. 1-2; pp. 17 - 23
Main Authors YANG, Si H, LEE, Myung G
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier 2007
Subjects
Biological and medical sciences
General pharmacology
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Stomach
Pharmaceutical technology
Intravenous administration
Rat
Clindamycin
Rodentia
Oral administration
Bioavailability
Gastrointestinal
Vertebrata
Antibiotic
Mammalia
Clindamycin; Dose-independent pharmacokinetics; Intravenous
intragastric
Animal
First pass effect
and intraduodenal administration; Gastric first-pass effect; Rats
Intraduodenal administration
oral
intraportal
Antibacterial agent
Pharmacokinetics
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ISSN:0378-5173
1873-3476