Synthesis and biological evaluation of 14-alkoxymorphinans. 22.1 Influence of the 14-alkoxy group and the substitution in position 5 in 14-alkoxymorphinan-6-ones on in vitro and in vivo activities

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Bibliographic Details
Published inJournal of medicinal chemistry Vol. 48; no. 9; pp. 3372 - 3378
Main Authors LATTANZI, Roberta, SPETEA, Mariana, SCHÜLLNER, Falko, RIEF, Silvia B, KRASSNIG, Roland, NEGRI, Lucia, SCHMIDHAMMER, Helmut
Format Journal Article
LanguageEnglish
Published Washington, DC American Chemical Society 2005
Subjects
Analgesics
Biological and medical sciences
Medical sciences
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems
Pharmacology. Drug treatments
Morphinan derivatives
Morphine derivatives
Opioid receptor
Rodentia
Molecular interaction
Opiates
In vitro
Biological activity
In vivo
Vertebrata
Alkaloid
Biological fixation
Mammalia
Mouse
Animal
Digestive diseases
Intestinal disease
Subcutaneous administration
Chemical synthesis
Constipation
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ISSN:0022-2623
1520-4804