Novel thrombin inhibitors incorporating weakly basic heterobicyclic P1-arginine mimetics: optimization via modification of P1and P3 moieties

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 14; no. 12; pp. 3251 - 3256
Main Authors KRANJC, Andreja, PETERLIN-MASIC, Lucija, ILAS, Janez, PREZELJ, Andrej, STEGNAR, Mojca, KIKELJ, Danijel
Format Journal Article
LanguageEnglish
Published Oxford Elsevier 2004
Subjects
Biological and medical sciences
Medical sciences
Miscellaneous
Pharmacology. Drug treatments
Serine endopeptidases
Enzyme
Mimetic
Thrombin
Selectivity
Benzothiazole derivatives
Indazole derivatives
Biological activity
Peptidases
Racemic
Amine
Side chain
Arginine
Aminoacid
Hydrolases
Inhibitor
Chemical synthesis
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ISSN:0960-894X
1464-3405