Identification of the first trans-(3R, 4R)-dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid k receptor antagonist activity

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Bibliographic Details
Published inJournal of medicinal chemistry Vol. 44; no. 17; pp. 2687 - 2690
Main Authors THOMAS, James B, ATKINSON, Robert N, ZIMMERMAN, Dennis M, CARROLL, F. Ivy, ROTHMAN, Richard B, FIX, Scott E, MASCARELLA, S. Wayne, VINSON, N. Ariane, HENG XU, DERSCH, Christina M, LU, Y.-F, CANTRELL, Buddy E
Format Journal Article
LanguageEnglish
Published Washington, DC American Chemical Society 2001
Subjects
Biological and medical sciences
Medical sciences
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems
Pharmacology. Drug treatments
Nitrogen heterocycle
Rodentia
Central nervous system
κ Opioid receptor
Selectivity
In vitro
Biological activity
Stereoselectivity
Vertebrata
Mammalia
Guinea pig
Animal
Trans stereoisomer
Piperidine derivatives
Bicyclic compound
Phenols
Affinity
Carboxamide
Benzenic compound
Aromatic compound
Antagonist
Chemical synthesis
Brain (vertebrata)
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ISSN:0022-2623
1520-4804