Immunoglobulin. gamma. light-chain-related genes 14. 1 and 16. 1 are expressed in pre-B cells and may encode the human immunoglobulin. omega. light-chain protein

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 86:14
• Main Authors: Hollis, G.F., Evans, R.J., Stafford-Hollis, J.M., Korsmeyer, S.J., McKearn, J.P.
• Format: Journal Article
• Language: English
• Published: United States 01.07.1989
• Subjects: 550201 - Biochemistry- Tracer Techniques; AMINO ACIDS; ANIMAL CELLS; BASIC BIOLOGICAL SCIENCES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CARBOXYLIC ACIDS; CONNECTIVE TISSUE CELLS; DAYS LIVING RADIOISOTOPES; DNA; DNA SEQUENCING; DRUGS; EVEN-ODD NUCLEI; GENE REGULATION; GENES; GLOBULINS; IMMUNOGLOBULINS; ISOTOPES; LEUKOCYTES; LIGHT NUCLEI; LIPOTROPIC FACTORS; LYMPHOCYTES; MATERIALS; METHIONINE; NUCLEI; NUCLEIC ACIDS; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; PHOSPHORUS 32; PHOSPHORUS ISOTOPES; PROTEINS; RADIOISOTOPES; RECOMBINANT DNA; SOMATIC CELLS; STRUCTURAL CHEMICAL ANALYSIS; SULFUR 35; SULFUR ISOTOPES; TRANSCRIPTION; TUMOR CELLS

Human pre-B cells, which produce immunoglobulin heavy chain but do not produce immunoglobulin light chain, are shown to contain a 1-kilobase transcript homologous to immunoglobulin {lambda} light-chain genes. Detailed analysis of RNA and cDNA clones derived from these transcripts reveals that they o...