Circular RNA hsa{sub c}irc{sub 0}023404 exerts an oncogenic role in cervical cancer through regulating miR-136/TFCP2/YAP pathway

• Published in: Biochemical and biophysical research communications Vol. 501; no. 2
• Main Authors: Zhang, Jianhua, Zhao, Xinyuan, Zhang, Jin, Zheng, Xuerong, Li, Fenxia
• Format: Journal Article
• Language: English
• Published: United States 15.06.2018
• Subjects: 60 APPLIED LIFE SCIENCES; CELL CYCLE; NEOPLASMS; PORIFERA; RNA; WOMEN
• ISSN: 0006-291X; 1090-2104

Cervical cancer (CC) is one of the most prevalent malignances among women. However, the mechanism underlying CC development remains elusive. Recently, circular RNAs (circRNAs) have been known as important regulators in tumorigenesis. Whether circRNAs are involved in CC requires to be determined. In the present study, we found that circRNA hsa{sub c}irc{sub 0}023404 was significantly upregulated in CC tissues compared to adjacent normal tissues. And its overexpression was correlated with poor prognosis in CC patients. Functionally, we showed that knockdown of hsa{sub c}irc{sub 0}023404 significantly suppressed the proliferation, arrested the cell-cycle progression and inhibited cell migration and invasion in CC. In terms of mechanism, we found that hsa{sub c}irc{sub 0}023404 acted as a sponge of miR-136 and miR-136 targeted TFCP2, which is an activator of YAP signaling pathway. We showed that hsa{sub c}irc{sub 0}023404 activated YAP pathway in CC via promoting TFCP2 expression by sponging miR-136, leading to CC development and progression. Taken together, our study for the first time demonstrated the pivot role of hsa{sub c}irc{sub 0}023404 and revealed a novel regulatory loop of hsa{sub c}irc{sub 0}023404/miR-136/TFCP2/YAP axis in CC progression.