Magnetic Resonance Imaging with laser polarized {sup 129}Xe

Magnetic Resonance Imaging with laser-polarized {sup 129}Xe can be utilized to trace blood flow and perfusion in tissue for a variety of biomedical applications. Polarized xenon gas introduced in to the lungs dissolves in the blood and is transported to organs such as the brain where it accumulates...

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Bibliographic Details
Published inAIP conference proceedings Vol. 421; no. 1
Main Authors Swanson, Scott D., Rosen, Matthew S., Agranoff, Bernard W., Coulter, Kevin P., Welsh, Robert C., Chupp, Timothy E.
Format Journal Article
LanguageEnglish
Published United States 20.01.1998
Subjects
BLOOD
BLOOD FLOW
BRAIN
HEAD
IMAGE PROCESSING
LASER RADIATION
LUNGS
NMR IMAGING
NUCLEAR MAGNETIC RESONANCE
ORIENTED NUCLEI
POLARIZATION
RADIOLOGY AND NUCLEAR MEDICINE
RATS
XENON 129
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Summary:Magnetic Resonance Imaging with laser-polarized {sup 129}Xe can be utilized to trace blood flow and perfusion in tissue for a variety of biomedical applications. Polarized xenon gas introduced in to the lungs dissolves in the blood and is transported to organs such as the brain where it accumulates in the tissue. Spectroscopic studies combined with imaging have been used to produce brain images of {sup 129}Xe in the rat head. This work establishes that nuclear polarization produced in the gas phases survives transport to the brain where it may be imaged. Increases in polarization and delivered volume of {sup 129}Xe will allow clinical measurements of regional blood flow.
ISSN:0094-243X
1551-7616
DOI:10.1063/1.55021