Measurement of Swine H1N1 Hemagglutinin Peptide binding with Piezoresistive Microcantilever Arrays

The effective detection of Swine H1N1 Hemagglutinin peptide is crucial as it could be used as a positive control to screen for highly infectious flu strains such as Swine-Origin Influenza A (H1N1). Piezoresistive microcantilever arrays present a pathway towards highly sensitive and label-free detect...

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Bibliographic Details
Published inAIP advances Vol. 4; no. 3
Main Authors Bajwa, Navdeep K, Maldonado, Carlos J., Thundat, Thomas George, Passian, Ali
Format Journal Article
LanguageEnglish
Published United States American Institute of Physics (AIP) 24.03.2014
Subjects
BASIC BIOLOGICAL SCIENCES
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Summary:The effective detection of Swine H1N1 Hemagglutinin peptide is crucial as it could be used as a positive control to screen for highly infectious flu strains such as Swine-Origin Influenza A (H1N1). Piezoresistive microcantilever arrays present a pathway towards highly sensitive and label-free detection of biomolecules by transducing the antigen-antibody binding into change in resistivity via induced surface stress variation. We also demonstrate a mechanical transduction of Swine H1N1 Hemagglutinin peptide binding and suggest the employed technique may offer a potential platform for detection of the H1N1 virus, which could be clinically used to diagnose and provide subsequent relief.
Bibliography:USDOE
AC05-00OR22725
ISSN:2158-3226
2158-3226