모성 당뇨병과 극소저체중 출생아 예후의 연관성

• Published in: Perinatology (Online) pp. 177 - 183
• Main Authors: 송지인, 정의석, 오문연, 정지윤, 차태현, 고승현, 이병섭, Ellen Ai-Rhan Kim, 김기수
• Format: Journal Article
• Language: Korean
• Published: 대한주산의학회 01.12.2021
• Subjects: 의학일반
• ISSN: 2508-4887; 2508-4895
• DOI: 10.14734/PN.2021.32.4.177

Objective: Women with diabetes mellitus (DM) are at high risk for preterm delivery. However, reported findings on the effects of maternal diabetes on the outcome of very low birth weight infants (VLBWIs) are inconsistent. This study compared the mortality and morbidity among VLBWIs born to women with and without DM. Methods: In this retrospective cohort study, we included data on VLBWI without congenital malformations born between April 2013 and September 2020. Neonatal outcomes according to maternal diabetes, type of diabetes, and maternal insulin treatment were compared using multivariate logistic analysis. Results: Of 756 infants, 61 were born to women with DM. Of these 61 mothers, 55 had gestational DM, while 6 had pregestational DM. After adjusting for confounders, it was observed that VLBWI born to women with diabetes were less likely to develop sepsis. The risk of grade 3 or 4 intraventricular hemorrhage (IVH) was higher in the insulin-requiring DM group. There was no significant difference in the mortality of VLBWI under any maternal condition. Conclusion: Maternal diabetes lowers the prevalence of sepsis in VLBWI, which is particularly augmented in the insulin-requiring DM group. However, maternal insulin treatment increases the incidence of severe IVH in VLBWI. KCI Citation Count: 0