Synthesis of dimeric fluorescent TSPO ligand for detection of glioma
TSPO, an 18-kDa translocator protein, is a peripheral-type benzodiazepine receptor that has been associated to a variety of biological activities such as apoptosis, steroidogenesis, and cell proliferation. Because TSPO overexpression has been found in various forms of cancer, it has recently become...
Saved in:
| Published in | 대한방사성의약품학회지, 7(1) pp. 56 - 65 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
대한방사성의약품학회
01.06.2021
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Summary: | TSPO, an 18-kDa translocator protein, is a peripheral-type benzodiazepine receptor that has been associated to a variety of biological activities such as apoptosis, steroidogenesis, and cell proliferation. Because TSPO overexpression has been found in various forms of cancer, it has recently become one of the most appealing biological targets for cancer therapies and detection. In order to create new optical imaging agents for improved diagnostics, we synthesized a novel dimeric fluorescent TSPO ligand based on PRB28 structure and SCy5.5.
Following the preparation of the novel TSPO ligand, in vivo and ex vivo imaging tests were performed to examine the tumor uptake characteristics of the fluorescent TSPO ligand in a glioma animal model, and it was found that novel TSPO ligand was accumulated in glioma. These results suggested that novel dimeric fluorescent TSPO ligand will be applied to detect glioma. KCI Citation Count: 0 |
|---|---|
| ISSN: | 2384-1583 2508-3848 |