청소년기 자살에 대한 뇌상 연구

• Published in: Journal of the Korean Society of Biological Psychiatry pp. 36 - 49
• Main Authors: 이수지, 김신혜, 윤수정
• Format: Journal Article
• Language: Korean
• Published: 대한생물정신의학회 01.10.2021
• Subjects: 정신과학
• ISSN: 1225-8709; 1225-8709
• DOI: 10.22857/kjbp.2021.28.2.002

Suicide is a leading cause of death worldwide, especially among adolescents and young adults. Considering this fact, it is imperative that we understand the neural mechanisms underlying suicidal thoughts and behaviors in youth from a neurodevelopmental perspective. In this review, we focused on the magnetic resonance imaging studies that examined the neural correlates of suicidal ideations (SI) or attempts (SA) in youth. We reviewed twenty-three cross-sectional studies reporting the structural and functional alterations in association with SI or SA among adolescents and young adults with various mental disorders. The previous literature suggests that the dorsolateral prefrontal cortex, anterior cingulate cortex, and ventral frontolimbic circuit, may play an important role in the pathophysiology of suicidal behavior in youth through altered top-down control over emotion and impulsivity. Future studies with a longitudinal design and using multimodal imaging techniques may be of help to identify novel therapeutic targets specific for youth with suicidal thoughts and behaviors. KCI Citation Count: 0