Comparative Study of the Biological Activity of Propolis Extracts with Various Countries of Origin as Cosmetic Materials

• Published in: 대한화장품학회지, 46(2) pp. 159 - 166
• Main Authors: 정은선, 원진배(바이오스펙트럼, 지향기(바이오스펙트럼, 유지영(바이오스펙트럼, 오세영(바이오스펙트럼, 김하연(바이오스펙트럼, 신영희(바이오스펙트럼, 김은빈(바이오스펙트럼, 허강혁(바이오스펙트럼, 박덕훈(바이오스펙트럼
• Format: Journal Article
• Language: English
• Published: 사단법인 대한화장품학회 01.06.2020
• Subjects: 피부과학
• ISSN: 1226-2587; 2288-9507
• DOI: 10.15230/SCSK.2020.46.2.159

Propolis is a sticky resinous substance that is formed by the combination of honeybee secretions and resin of plants, which serves to protect from bacteria and viruses. This study aims to evaluate the efficacy of propolis extract from Korea (KPE), China (CPE), and Brazil (BPE) through antioxidant, antibacterial, whitening, and anti-inflammatory tests, and to examine their potential as cosmetic materials. KPE, CPE, and BPE showed significant antioxidant activities on flavonoid/polyphenol content and free radical scavenging activity. The antibacterial effect of propolis on skin flora was determined by measuring the minimal inhibitory concentration (MIC). KPE showed better antibacterial efficacy than CPE and BPE in C. acnes (KPE, CPE, and BPE: (62.5, 250, and 500) μg/mL, respectively). Furthermore, KPE inhibited the melanin synthesis in human epidermal melanocytes and production of nitric oxide and PGE2 induced by lipopolysaccharide (LPS) in mouse macrophages, which showed better than did CPE or BPE. Taken together, the propolis extracts can be applied to antioxidant, antibacterial, and anti-inflammatory ingredient for cosmetics, while KPE showed superior potential in antibacterial, anti-inflammatory, and whitening efficacies. KCI Citation Count: 0