녹용대보탕이 β-Amyloid로 誘導된 Alzheimer's Disease 病態 모델에 미치는 影響

• Published in: 동의신경정신과학회지, 18(2) pp. 101 - 132
• Main Authors: 정대규, 서규태, 이은경, 최철홍
• Format: Journal Article
• Language: Korean
• Published: 대한한방신경정신과학회 01.07.2007
• Subjects: 한의학
• ISSN: 1226-6396; 2234-4942

Abatract Objective : This research investigates the effect of the NogYongDaeBoTang,(NYDBT) on Alzheimer's disease. Method : The effects of the NYDBT extract on (1) IL-1β, IL-6, and TNF-α mRNA of PC-12 cells treated with LPS; (2) acetylcholinesterase(AChE), amyloid precursor proteins(APP), and glial fibrillary acidic protein(GFAP) mRNA the AChE activity and the APP production of PC-12 cell treated with CT-105; (3) the behavior; (4) expression of IL-1β, TNF-α, MDA, IL-1β mRNA, and TNF-α mRNA; (5) the infarction area of the hippocampus, and brain tissue injury in Alzheimer's diseased mice induced with βA were investigated. Results : 1. The NYDBT extract suppressed the expression of IL-1β, IL-6 and TNF-α mRNA in BV2 microglia cell line treated with LPS. 2. The NYDBT extract suppressed the expression of IL-1β, IL-6, and TNF-α protein production in BV2 microglia cell line treated with LPS. 3. For the NYDBT extract group a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer's disease induced by Aβ in the Morris water maze experiment, which measured stop-through latency, and distance movement-through latency. 4. The NYDBT extract suppressed the over-expression of IL-1β protein, TNF-α protein, MDA, and CD68/CD11b, in the mice with Alzheimer's disease induced by Aβ. 5. The NYDBT extract reduced the infarction area of hippocampus, and controlled the injury of brain tissue in the mice with Alzheimer's disease induced by Aβ. KCI Citation Count: 0