폰레클링하우젠병에 동반된 위장관간질종양 - CD117, CD34, SMA, S-100 단백에 모두 양성반응을 보인 위장관간질종양

• Published in: Annals of surgical treatment and research pp. 65 - 69
• Main Authors: 배성우, 유진예, 문화숙, 홍숙희
• Format: Journal Article
• Language: Korean
• Published: 대한외과학회 01.01.2006
• Subjects: 일반외과학
• ISSN: 2288-6575; 2288-6796

Gastrointestinal stromal tumors (GISTs) are CD117-positive primary mesenchymal tumors of the gastrointestinal tract and they have a characteristic set of morphologic features. GISTs have been noted to have a possible non-random association with neurofibromatosis-1 (NF-1, von Recklinghausen disease). We report here on a case of multiple GISTs with abundant skenoid fiber in the jejunum of a 47-year-old woman, and this condition was accompanied with NF-1. The tumor cells coexpressed smooth muscle actin, S-100 protein, CD117 and CD34. These immunohistochemical results are extremely rare findings for GISTs accompanying with NF-1. We think this is the first report of GISTs arising within NF-1 with the dual immunohistochemical differentiation of neuronal and muscular markers. (J Korean Surg Soc 2006;70:65-69) KCI Citation Count: 0