대장 종양에서 CD43의 발현에 관한 연구

• Published in: Journal of pathology and translational medicine pp. 8 - 14
• Main Authors: 정경천, 배영미, 안혜경, 김혜은, 장명철, 노혜린, 채기봉, 최원진, 김우진, 박원서
• Format: Journal Article
• Language: Korean
• Published: 대한병리학회 01.02.2004
• Subjects: 병리학
• ISSN: 2383-7837; 2383-7845

Background : CD43 is a sialoglycoprotein that is highly expressed on most leukocytes, except on B lymphocytes and dendritic cells. CD43 has been reported to be involved in the adhesion and apoptosis of lymphocytes. Although the aberrant expression of CD43 antigen in non-lymphoid tissues has been reported, the expression of the CD43 antigen in gastrointestinal malignancies is not well studied. Here, we studied the expression of CD43 in colon adenocarcinoma using the anti-CD43 monoclonal antibody developed in our laboratory. Methods : Thirty patients who had undergone surgical resection for colorectal carcinoma were recruited. The expression of CD43 molecule was determined by analyzing the formalin-fixed, paraffinembedded specimens immunohistochemically using our newly developed anti-CD43 mAb (K06). The results obtained by the immunohistochemical analysis correlated to the clinicopathological parameters. Results : The expression of CD43 were found in 20 out of 30 colorectal carcinoma cases. The expression of CD43 antigen is higher in well differentiated adenocarcinomas than poorly or moderately differentiated adenocarcinomas. Conclusions : The new anti- CD43 mAb might be helpful for the detection of the expression of CD43 on colorectal carcinoma cells. Further studies are required to assess the relationship between the CD43 expression and the colorectal carcinogenesis. KCI Citation Count: 0