A Metastatic Granulocyte Colony-Stimulating Factor Producing Sarcomatoid Carcinoma of the Lung Causing Jejunal Intussusception - Report of a Case

• Published in: Journal of pathology and translational medicine pp. 205 - 208
• Main Authors: 홍민의, 홍순억, 권기영, 이태진, 박언섭, 차성재, 도재혁, 유재형
• Format: Journal Article
• Language: English
• Published: 대한병리학회 01.04.2011
• Subjects: 병리학
• ISSN: 2383-7837; 2383-7845

A 75-year-old man was referred to our hospital with intestinal obstruction caused by intussuscep­tion. Abdominal computed tomography (CT) revealed seven polypoid masses in the small intes­tine, while chest CT revealed a mass in the right lower lobe. Preoperative laboratory tests showed white blood cell (WBC) and neutrophil differential counts of 63,630/mm³ and 95%, respectively. The serum granulocyte colony-stimulating factor (G-CSF) was 114 pg/mL, which was elevated (normal range, <18.1 pg/mL). After resection of the small bowel, the WBC count decreased to 20,510/mm³. The pathology showed a poorly differentiated carcinoma with sarcomatous compo­nents confirmed by positive immunostaining of cytokeratin (AE1/AE3) and vimentin in the small intestine. Furthermore, immunohistochemistry with specific monoclonal antibodies against G-CSF was positive. A lung biopsy revealed the same histological findings as the small intestine le­sion. Therefore, the patient was diagnosed as having a G-CSF producing sarcomatoid carcinoma of the lung with metastasis to the small intestine KCI Citation Count: 0