Determination of Parathion Metabolite, p-Nitrophenolin Urine of Parathion Factory Workers

• Published in: Bulletin of the Korean Chemical Society pp. 985 - 987
• Main Authors: 한돈희, 정동균, 신호상
• Format: Journal Article
• Language: English
• Published: 대한화학회 01.05.2008
• Subjects: 화학
• ISSN: 0253-2964; 1229-5949

Parathion is an organophosphate pesticide being legally applied for the purpose of agriculture and is being manufactured in Korea. A gas chromatography/mass spectrometric method was developed for the determination of parathion urinary metabolite, p-nitrophenol. p-Nitrophenol was extracted from weak acidic urine, and then measured by gas chromatography-mass spectrometry (selected ion monitoring). The recovery of p-nitrophenol in the overall procedure was 88.2%. The detection limit of the assay was 1.0 m g/L based upon assayed urine of 2.0 mL. The method was applied to the determination of p-nitrophenol in urine of workers of a parathion industry. Spot urines of workers of a parathion industry were sampled at the end of shift and p-nitrophenol was analyzed using above developed method. p-Nitrophenol could be detected in all of the urine samples at concentrations varying from 3.0 to 681 m g/L. Parathion is an organophosphate pesticide being legally applied for the purpose of agriculture and is being manufactured in Korea. A gas chromatography/mass spectrometric method was developed for the determination of parathion urinary metabolite, p-nitrophenol. p-Nitrophenol was extracted from weak acidic urine, and then measured by gas chromatography-mass spectrometry (selected ion monitoring). The recovery of p-nitrophenol in the overall procedure was 88.2%. The detection limit of the assay was 1.0 m g/L based upon assayed urine of 2.0 mL. The method was applied to the determination of p-nitrophenol in urine of workers of a parathion industry. Spot urines of workers of a parathion industry were sampled at the end of shift and p-nitrophenol was analyzed using above developed method. p-Nitrophenol could be detected in all of the urine samples at concentrations varying from 3.0 to 681 m g/L. KCI Citation Count: 7