혈청 항중성구세포질항체 (ANCA) 양성으로 발현한 아급성 심내막염 1예

• Published in: Kidney research and clinical practice pp. 476 - 480
• Main Authors: 안선호, 최준호, 정덕은, 류한승, 김현정, 이유민, 이재훈, 이지은, 신진호, 송주홍
• Format: Journal Article
• Language: Korean
• Published: 대한신장학회 01.07.2008
• Subjects: 내과학
• ISSN: 2211-9132; 2211-9140

Antineutrophil cytoplasmic antibodies (ANCA) directed against either proteinase-3 or myeloperoxidase are associated with a limited group of small vessel vasculitic syndromes. C-ANCA is regarded as highly specific for idiopathic ANCA-associated vasculitis (AAV). However, C-ANCA is not specific for Wegeners granulomatosis and has been reported in the course of a variety of infectious conditions. Sub-acute bacterial endocarditis is a notable concern because it may be associated with C-ANCA. The misdiagnosis of bacterial endocarditis as AAV and the administration of immunosuppressive treatment could aggravate the infection. We describe a patient with sub-acute bacterial endocarditis who presented with features mimicking vasculitis and positive C-ANCA by indirect immunofluorescence and for anti-PR3 antibodies by antigen-specific ELISA. KCI Citation Count: 0