방사선조사가 당뇨 백서의 측두하악관절에 미치는 영향

• Published in: Imaging science in dentistry pp. 81 - 89
• Main Authors: 안기동, 황의환, 이상래
• Format: Journal Article
• Language: Korean
• Published: 대한영상치의학회 01.06.2004
• Subjects: 치의학
• ISSN: 2233-7822; 2233-7830

Purpose : To investigate the histopathological changes in the temporomandibular joint in streptozotocin-induced diabetic rat following irradiation.Materials and Methods : Sprague-Dawley rats weighing about 250 gm were divided into three groups: control, diabetic, and diabetic-irradiated groups. Diabetes mellitus was induced in the rats by injecting streptozotocin. Rats in the control group were injected with citrate buffer only. After 5 days, the head and neck region of the rats in diabeticirradiated group were irradiated with single absorbed dose of 10 Gy. The rats were killed at 1, 3, 7, 14, 21, and 28 days after irradiation. The specimen including the temporomandibular joint were sectioned and observed using a histopathological method.Results : In the diabetic group, severe bone resorption in the mandibular condyle was observed throughout the period of experiment. Necrosis of bone marrow and trabeculae was observed at 28 days after diabetic state. Atrophy and fibrosis in the retrodiscal tissue was gradually progressed during the time of the experiment. In the diabeticirradiated group, severe bone resorption in the mandibular condyle was observed during the early experimental phases, but regeneration of bone marrow was initiated at 14 days after diabetic state and irradiation. Also, calcification of abnormal trabeculae was observed at 28 days after diabetic state and irradiation. The retrodiscal tissue was degenerated in the early experimental phases, but it had been gradually regenerated during the experimental time.Conclusion : This experiment suggests that bone resorption and degeneration in the mandibular condyle are caused by the induction of diabetes, and abnormal bone formation is induced after irradiation in diabetic state. (Korean J Oral Maxillofac Radiol 2004; 34 : 81-9) KCI Citation Count: 0