Hyperventilation delays clinical induction of desflurane

• Published in: Anesthesia and pain medicine (Korean society of anesthesiologists) pp. 216 - 221
• Main Authors: 이윤석, 인준용, 김경옥, 윤동일, 이정혁, 조헌, 최준권, 정승현, 장은정
• Format: Journal Article
• Language: English
• Published: 대한마취통증의학회 01.07.2010
• Subjects: 마취과학
• ISSN: 1975-5171; 2383-7977

Background:Ventilation is a major determinant of the alveolar concentration of inhaled anesthetics. Hyperventilation accelerates the equilibration of anesthetic in the lungs, but decelerates it in the brain. We evaluated this phenomenon for desflurane. Methods:Twenty healthy subjects were enrolled after IRB approval. End-tidal concentrations of desflurane (P.DESF) were recorded during 10 minutes of mask induction with 8% desflurane. P.DESF was modeled with time and end-tidal concentrations of CO2 (P.ETCO2) using a two-exponential pharmacokinetic equation. Bispectral index (BIS) values were also measured to find out the component reflecting the cerebral concentration of desflurane. Results:During induction, the rise of P.DESF could be separated into two components: early and late rises. Individual BIS values showed a higher correlation with the late component of P.DESF (P = 0.000). P.ETCO2 had two different effects on the rise of P.DESF. Conclusions:Hyperventilation hastened the early rise and delayed the late rise of P.DESF (P = 0.00, P = 0.00). Hyperventilation should be avoided to obtain rapid anesthesia induction with desflurane. KCI Citation Count: 1