Propofol 효과처농도 4μg/ml로 기관내 삽관을 할 경우Alfentanil 효과처 농도에 따른 혈압과 맥박의 변화

• Published in: Korean journal of anesthesiology pp. 155 - 161
• Main Authors: 노규정, 최병문, 구승우, 정성량
• Format: Journal Article
• Language: Korean
• Published: 대한마취통증의학회 01.08.2004
• Subjects: 마취과학
• ISSN: 2005-6419; 2005-7563

Background: Propofol and alfentanil are frequently combined for general anesthesia. The purpose of this study was to characterize the appropriate effect-site concentration of alfentanil combined with an effect-site concentration of propofol of 4μg/ml during endotracheal intubation. Methods: One hundred and thirty patients, aged 40-70 years and scheduled for abdominal surgery were randomly allocated to four groups according to the target effect-site concentrations of alfentanil: 0 ng/ml in the placebo group, 50 ng/ml in the P50 group, 75 ng/ml in the P75 group, and 100 ng/ml in the P100 group. All patients received a computer controlled infusion of propofol with an effect-site concentration of 4μg/ml. After equilibration between plasma and effect-site was achieved, and the trachea of the patient was intubated. The assessments of hemodynamic changes were usually confined to the measurement of changes in systolic/diastolic blood pressure (SBP/DBP), mean arterial pressure (MAP), and heart rate (HR). Also, we checked the dose requirements of ephedrine and atropine used to correct hypotension and bradycardia. Results: The use of alfentanil (especially 50 or 75 ng/ml) was effective at blunting the SBP increase during the few minutes after intubation. However, the dose requirements of ephedrine and atropine in the P100 group were significantly higher than those in other groups. Conclusions: The appropriate effect-site concentration of alfentanil combined with an effect-site concentration of propofol of 4μg/ml during endotracheal intubation lies between 50 and 75 ng/ml. (Korean J Anesthesiol 2004; 47: 155～61) KCI Citation Count: 0