간신증후군으로 오인하였던 메포르민에 의한 유산산증 1예

• Published in: The Korean journal of medicine pp. 241 - 246
• Main Authors: 김옥기, 옥찬영, 정지민, 이정원, 신민호, 김남호
• Format: Journal Article
• Language: Korean
• Published: 대한내과학회 01.02.2012
• Subjects: 내과학
• ISSN: 1738-9364; 2289-0769

저자들은 간경화 환자에서 메포르민에 의해 발생한 유산산증 및 급성 신손상 환자를 약물 복용력이 확인되지 않아 간신증후군으로 오진하였던 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Metformin is a well-established drug for the treatment of type 2 diabetes mellitus. The incidence of metformin-induced lactic acidosis is low, but the estimated mortality rate is approximately 50% in cases with lactic acidosis in combination with metformin therapy. Lactic acidosis occurs most often in patients with compromised cardiac, pulmonary, hepatic, and/or renal function. Acute kidney injury is a relatively frequent problem in cirrhosis patients. Hepatorenal syndrome is a diagnosis of exclusion, making its diagnosis difficult in the clinical field. We report a case of metformin-induced lactic acidosis with acute kidney injury that was misdiagnosed as hepatorenal syndrome in a cirrhosis patient. (Korean J Med 2012;82:241-246) KCI Citation Count: 3