Biocompatibility of β-Ti Alloy for Dental Implant

• Published in: Biomaterials research pp. 43 - 51
• Main Authors: Wang-Woo Lee, 권태엽, Won-Yong Kim, HyoJinLee, 김교한
• Format: Journal Article
• Language: English
• Published: 한국생체재료학회 01.06.2011
• Subjects: 의공학
• ISSN: 1226-4601; 2055-7124

Beta-titanium alloys have widely been used for biomedical applications. Biocompatibility of the beta type Ti-Nb-Ge alloys for use of dental implant was evaluated according to the ISO 10993 and their cellular responses were evaluated. No systemic toxicity was found in the material tested in this study (acute systemic toxicity test). In addition,neither erythema nor eschar formation was observed (intracutaneous reactivity test). MTT assay results also showed that there was no cytotoxic effect. The proliferation of the MG63 cells cultured on Ti-26Nb-0.5Ge and Ti-24Nb-1.0Ge alloys was more prominent than that on pure titanium. MG63 cells grown on Ti-24Nb-1.0Ge and Ti-26Nb-0.5Ge surfaces produce higher ALP activity than pure titanium control. Cells on Ti-24Nb-1.0Ge produce two fold ALP activity in comparison with pure titanium. Two kinds of titanium alloy such as Ti-24Nb-1.0Ge and Ti-26Nb-0.5Ge promoted osteopontin and osteocalcin gene expressions of MG63 more effectively than pure titanium. KCI Citation Count: 0