이중 리간드를 이용한 암 표적지향의 최근 연구동향

• Published in: Biomaterials research pp. 112 - 115
• Main Authors: 배진우, 박기동
• Format: Journal Article
• Language: Korean
• Published: 한국생체재료학회 01.09.2012
• Subjects: 의공학
• ISSN: 1226-4601; 2055-7124

For the past few decades, great advances have been made in cancer treatment using targeted drug delivery systems that utilize specific receptor-ligand interactions. Some targeted nanocarriers have shown clinically promising results. Considering cancer microenvironments that are very complex and dynamic, however, nanocarrier-based drug delivery platforms decorated with a single ligand that can specifically bind to receptors over-expressed on cancer cells may cause adverse effects because the ligand can be also recognized by normal cells. This review mainly focuses on a dualligand approach of nanocarriers that simultaneously exploits two different types of cancer targeting ligands, which can improve cancer targetability of the nanocarriers. We will first discuss general features of current nanocarrier platforms in brief and then introduce the recent achievement based on a dual-ligand approach. KCI Citation Count: 0