Infliximab으로 호전된 장관 증상없이 발생한 구강-안면 크론병 1예

• Published in: The Korean journal of gastroenterology pp. 437 - 440
• Main Authors: 정보용, 이석호, 정승규, 이창균, 이태훈, 정일권, 김선주, 조현득
• Format: Journal Article
• Language: Korean
• Published: 대한소화기학회 01.06.2012
• Subjects: 내과학
• ISSN: 1598-9992; 2233-6869

Crohn’s disease is a chronic inflammatory bowel disease that can involve the whole gastrointestinal tract. The orofacial manifestation of Crohn’s disease, which is rare, can develop irrespective of intestinal involvement. These orofacial lesions are often misdiagnosed as simple oral ulcers. Corticosteroids are the mainstay of therapy for orofacial Crohn’s disease. However, infliximab,the chimeric monoclonal antibody to tumor necrosis factor-α, is now considered as a primary treatment because of the disease’s relatively high rate of steroid resistance.　We present a case of deep oral ulcer and periorbital swelling in a 65-year-old woman. She was diagnosed with intestinal Crohn’s disease 7 years ago, which was in remission after treatment with an immunosuppressive agent (azathioprine). The patient was given the diagnosed with orofacial Crohn’s disease and successfully treated with infliximab. KCI Citation Count: 0