건강검진 환자에서 Polyethylene Glycol with Ascorbic Acid를 이용한 대장내시경 전처치에서 Simethicone 병합, 물 1 L 추가 복용의 효과 비교: 전향적 무작위 대조군 연구

• Published in: The Korean journal of gastroenterology pp. 189 - 197
• Main Authors: 여세환, 곽재훈, 김여운, 권태호, 박정배, 박준형, 이용국, 임윤정, 양창헌
• Format: Journal Article
• Language: Korean
• Published: 대한소화기학회 01.04.2016
• Subjects: 내과학
• ISSN: 1598-9992; 2233-6869

Background/Aims: There are no studies that looked into the bubble eliminating efficacy of polyethylene glycol with ascorbic acid (PEGA), which has been one of the shortcomings of polyethylene glycol (PEG). In this study, we compared newly introduced PEGA regimen by adding either simethicone or 1 L of water. Methods: A prospective randomized controlled study was carried out at Dongguk Universtiy Gyeongju Hospital from July 2014 to September 2014. A total of 90 patients were randomly assigned to 3 groups; PEGA group (n=30) which served as control, simethicone addition group (n=30) to which simethicone 400 mg was additionally prescribed, and water addition group (n=30) to whom additional 1 L of water was given. Cleansing effectiveness, gas elimination efficacy, side effects, and patient satisfaction were compared between the groups. Results: PEGA group demonstrated the highest cleansing effectiveness, but there was no statistically significant difference among the groups. Simethicone addition group showed significantly lesser amount of bubbles than the other groups (2.57±2.05 vs. 1.10±1.83 vs. 2.60±2.84, p=0.017). The rates of side effects in each group were 20.00% vs. 16.77% vs. 53.33%. Water addition group had significantly more side effects than the PEGA group and the simethicone addition group (p=0.003). The patient satisfaction score of each group was 3.37±0.85 vs. 3.73±0.74 vs. 3.20±0.66 with simethicone addition group showing significantly higher satisfaction than water addition group (p=0.020). Conclusions: PEGA bowel preparation agent showed satisfactory bowel cleansing despite the decrease in dosage, and addition of simethicone resulted in better bubble elimination. KCI Citation Count: 2