The Prevalence and Severity of Neuropsychiatric Symptoms in Alzheimer’s Disease and Subcortical Vascular Dementia : the CREDOS Study

• Published in: Noin chŏngsin ŭihak pp. 70 - 75
• Main Authors: 안호영, 정찬승, 이중선, 김도관, 이재홍, 김상윤, 한설희, 나덕렬, 김성윤
• Format: Journal Article
• Language: English
• Published: 대한노인정신의학회 01.12.2011
• Subjects: 정신과학
• ISSN: 1226-6329; 2733-4600

Objectives:This study aimed to compare the prevalence and severity of clinically relevant neuropsychiatric symptoms between subjects with Alzheimer’s disease (AD) and subcortical vascular dementia (SVD). Methods:The CREDOS (Clinical Research for Dementia Of South Korea) is a multicenter longitudinal cohort study organized to evaluate the long-term outcome of dementia patients. Out of a total 3,080 subjects, we selected 1,392 AD subjects and 247 SVD subjects with mild to moderate levels of dementia. The Neuropsychiatric Inventory (NPI) and Clinical Dementia Rating Scale (C- DR), and CDR sum of box scores were used for evaluation. Results:After controlling for severity of dementia and duration of education, SVD subjects had relatively more symptoms of apathy compared to AD subjects (OR : 1.397, p=0.025). SVD subjects also had relatively higher NPI composite scores in the apa- thy domain compared to AD subjects, after controlling for severity of dementia, age and duration of education (F=7.88, p=0.01). Subjects with moderate levels of dementia had more frequent and severe neuropsychiatric symptoms compared to those with mild dementia. Conclusion:Symptoms of apathy were more prevalent and severe in subjects with SVD, compared to subjects with AD. KCI Citation Count: 0