Synthetic approaches toward [18F]Fluoromisonidazole as a hypoxia imaging maker

Hypoxia has been shown in many tumors because of a reduced oxygen condition. A useful approach to detect hypoxia is to use molecular imaging. Positron emission tomography (PET), one of the biomedical molecular imaging tools, is the most common non-invasive technique for providing information about p...

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Published in대한방사성의약품학회지, 1(1) pp. 9 - 14
Main Authors 권영도, 임석태, 정환정, 손명희, 김희권
Format Journal Article
LanguageEnglish
Published 대한방사성의약품학회 01.04.2015
Subjects
방사선과학
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Summary:Hypoxia has been shown in many tumors because of a reduced oxygen condition. A useful approach to detect hypoxia is to use molecular imaging. Positron emission tomography (PET), one of the biomedical molecular imaging tools, is the most common non-invasive technique for providing information about physiological and biological events such as diseases. In order to use the PET technique for healthcare, promising molecular probes such as PET tracers required. [18F]Fluoromisonidazole ([18F]FMISO) is the most widely used in PET tracers for hypoxia. In this review, major developments of the synthetic method of [18F]FMISO are discussed. J Radiopharm Mol Probes 1(1):9-14, 2015 KCI Citation Count: 0
ISSN:2384-1583
2508-3848