포도당으로 유도된 in vitro 뇌신경세포 독성에 대한다래 순 아세트산에틸 분획물의 보호 효과

The current study investigated in vitro anti-diabetic and neuroprotective effects of the ethyl acetate fraction in Actinidia arguta sprouts (EFAS), on H2O2 and high glucose-induced cytotoxicity in human neuroblastoma MC-IXC cells. EFAS had high total phenolic and total flavonoid contents. An assessm...

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Published in한국식품과학회지, 50(5) pp. 517 - 527
Main Authors 유슬기(경상대학교 응용생명과학부, 박선경(경상대학교 응용생명과학부, 김종민(경상대학교 응용생명과학부, 강진용(경상대학교 응용생명과학부, 박수빈(경상대학교 응용생명과학부, 한혜주(경상대학교 응용생명과학부, 김철우, 이욱, 허호진
Format Journal Article
LanguageKorean
Published 한국식품과학회 01.10.2018
Subjects
식품과학
Online AccessGet full text
ISSN0367-6293
DOI10.9721/KJFST.2018.50.5.517

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Abstract The current study investigated in vitro anti-diabetic and neuroprotective effects of the ethyl acetate fraction in Actinidia arguta sprouts (EFAS), on H2O2 and high glucose-induced cytotoxicity in human neuroblastoma MC-IXC cells. EFAS had high total phenolic and total flavonoid contents. An assessment of 2,2'-azino-bis (3-ethylbenzothiazoline-6- sulfonic acid) radical scavenging activity of EFAS, as well as its potential for inhibiting malondialdehyde production, indicated that EFAS may possess significant antioxidant properties. EFAS exerted inhibitory effects on α-glucosidase via glycemic regulation which forms advanced glycation end products. In addition, EFAS exhibited significant acetylcholinesterase inhibitory effects. Moreover, EFAS displayed protective effects against H2O2 and high glucose-induced cell death, and inhibited the generation of reactive oxygen species in MC-IXC cells. Finally, the main physiological compound of EFAS was identified via high performance liquid chromatography as a rutin. KCI Citation Count: 0
AbstractList The current study investigated in vitro anti-diabetic and neuroprotective effects of the ethyl acetate fraction in Actinidia arguta sprouts (EFAS), on H2O2 and high glucose-induced cytotoxicity in human neuroblastoma MC-IXC cells. EFAS had high total phenolic and total flavonoid contents. An assessment of 2,2'-azino-bis (3-ethylbenzothiazoline-6- sulfonic acid) radical scavenging activity of EFAS, as well as its potential for inhibiting malondialdehyde production, indicated that EFAS may possess significant antioxidant properties. EFAS exerted inhibitory effects on α-glucosidase via glycemic regulation which forms advanced glycation end products. In addition, EFAS exhibited significant acetylcholinesterase inhibitory effects. Moreover, EFAS displayed protective effects against H2O2 and high glucose-induced cell death, and inhibited the generation of reactive oxygen species in MC-IXC cells. Finally, the main physiological compound of EFAS was identified via high performance liquid chromatography as a rutin. KCI Citation Count: 0
Author 이욱
유슬기(경상대학교 응용생명과학부
김철우
허호진
박수빈(경상대학교 응용생명과학부
강진용(경상대학교 응용생명과학부
한혜주(경상대학교 응용생명과학부
박선경(경상대학교 응용생명과학부
김종민(경상대학교 응용생명과학부
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DocumentTitleAlternate Protective effect of ethyl acetate fraction from Actinidia arguta sprout against high glucose-induced in vitro neurotoxicity
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Title 포도당으로 유도된 in vitro 뇌신경세포 독성에 대한다래 순 아세트산에틸 분획물의 보호 효과
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