포도당으로 유도된 in vitro 뇌신경세포 독성에 대한다래 순 아세트산에틸 분획물의 보호 효과

• Published in: 한국식품과학회지, 50(5) pp. 517 - 527
• Main Authors: 유슬기(경상대학교 응용생명과학부, 박선경(경상대학교 응용생명과학부, 김종민(경상대학교 응용생명과학부, 강진용(경상대학교 응용생명과학부, 박수빈(경상대학교 응용생명과학부, 한혜주(경상대학교 응용생명과학부, 김철우, 이욱, 허호진
• Format: Journal Article
• Language: Korean
• Published: 한국식품과학회 01.10.2018
• Subjects: 식품과학
• ISSN: 0367-6293
• DOI: 10.9721/KJFST.2018.50.5.517

The current study investigated in vitro anti-diabetic and neuroprotective effects of the ethyl acetate fraction in Actinidia arguta sprouts (EFAS), on H2O2 and high glucose-induced cytotoxicity in human neuroblastoma MC-IXC cells. EFAS had high total phenolic and total flavonoid contents. An assessment of 2,2'-azino-bis (3-ethylbenzothiazoline-6- sulfonic acid) radical scavenging activity of EFAS, as well as its potential for inhibiting malondialdehyde production, indicated that EFAS may possess significant antioxidant properties. EFAS exerted inhibitory effects on α-glucosidase via glycemic regulation which forms advanced glycation end products. In addition, EFAS exhibited significant acetylcholinesterase inhibitory effects. Moreover, EFAS displayed protective effects against H2O2 and high glucose-induced cell death, and inhibited the generation of reactive oxygen species in MC-IXC cells. Finally, the main physiological compound of EFAS was identified via high performance liquid chromatography as a rutin. KCI Citation Count: 0