Brain Perfusion Correlates of Apathy in Alzheimer's Disea

• Published in: Dementia and neurocognitive disorders pp. 50 - 56
• Main Authors: 정현석, Ilhyang Kang, 임주연, Jong-Sik Park, Seung-Hee Na, Youngje Heo, 양영순, 정용안, 송인욱
• Format: Journal Article
• Language: English
• Published: 대한치매학회 01.06.2018
• Subjects: 신경과학
• ISSN: 1738-1495; 2384-0757
• DOI: 10.12779/dnd.2018.17.2.50

Background and Purpose: Apathy is one of the most common neuropsychiatric symptoms in patients with Alzheimer's disease (AD). It may have adverse impacts on the progression of AD. However, its neurobiological underpinnings remain unclear. The objective of this study was to investigate differences in regional cerebral blood flow (rCBF) between AD patients with apathy and those without apathy. Methods: Sixty-six apathetic AD patients and 66 AD patients without apathy completed Neuropsychiatric Inventory (NPI) and underwent technetium-99m hexamethylpropylene amine oxime single-photon emission computed tomography (SPECT) scans. Voxel-wise differences in rCBF between the 2 groups were examined. Association between rCBF and levels of apathy in the apathetic group was also assessed. Results: AD patients with apathy showed lower rCBF in the bilateral orbitofrontal cortex, left putamen, left nucleus accumbens, left thalamus, and bilateral insula than those without (all p <0.005). Mean perfusion across all significant clusters showed a negative linear correlation with NPI apathy score in AD patients with apathy (β=−0.25; p =0.04). Conclusions: Hypoperfusion in the prefrontal, striatal, and insular areas may be neural correlates of apathy in AD patients. KCI Citation Count: 0