Effect of oral administration of b-glucans derived from Aureobasidium pullulans SM-2001 in model mice and rat with atopic dermatitis-like phenotypes

• Published in: Food science and biotechnology pp. 1185 - 1192
• Main Authors: 김인성, 이승호, 김정아, 유다윤, 홍연희, 김재영, 임종민, 이상숙, 윤철희, 최인순, 조광근
• Format: Journal Article
• Language: English
• Published: 한국식품과학회 01.08.2018
• Subjects: 식품과학
• ISSN: 1226-7708; 2092-6456
• DOI: 10.1007/s10068-018-0322-4

In this study, we investigated the anti-atopic dermatitis (AD) activity of b-glucans derived from Aureobasidium pullulans SM-2001 (bGdAP). bGdAP was orally administered to AD animal models such as vasodilation, allergic pruritus and contact dermatitis. Administration of bGdAP attenuated the amount of Evans blue solution on vasodilation rat. Scratching behaviors, secretion of histamine and ear thickness were significantly (p\0.05) attenuated in the bGdAP-treated mouse groups. Interestingly, transcriptional expression of T-bet, a transcription factor for Th1 reactions, was increased, but that of GATA-3, a transcription factor for Th2 reactions, was attenuated in the bGdAP-treated groups (p\0.05). In addition, we found that reduced transcriptional expression of forkhead box P3 and galectin-9, regulators of regulatory T cells, was recovered in the bGdAP-treated groups (p\0.05). Taken together, these data indicate that administration of bGdAP could effectively attenuate ADlike phenotypes via regulation of Th1/Th2 transcriptional activity and Treg activation. KCI Citation Count: 5